الفهرس 
Aim of Studyيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Hyperoxaluria is a condition that occurs when there is too much oxalate in urine. Oxalate, a natural chemical in our body and also contained in some foods, is normally eliminated from the body through the kidneys in the urine. Too much oxalate in the body can cause some serious health problems. An excess amount of oxalate can combine with calcium in the urine and cause kidney stones and crystals to form. Recurrent kidney stones and crystals can damage the kidney and lead to kidney failure. In this respect hyperoxaluria constitutes a special problem. Medicinal plants are the nature’s gift to human beings to help them pursue a disease-free healthy life. Plants have been used as drugs by humans since thousands of years ago. The present work was thereby conducted to evaluate the potential effect of khella baladia in different concentrations on hyperoxaluria in male albino rats.
To achieve these aims, the design of this study was as follows:
Thirty-six adult male albino rats weighing (180±20) g were housed in individual stainless-steel cages under controlled environmental conditions, and fed for one week on standard diet prior to start feeding on experimental diet for acclimatization. Then, rats were randomly distributed into 6 equal groups, 6 rats each. group 1was fed on the standard diet and set as a negative control group (normal rats). The other 5 groups induced hyperoxaluria by adding EG 0.75% and NH4Cl 1% to the drinking water. One week after drinking water with EG and NH4Cl, the urine of each rat was collected for 24 hours and it analyzed for determination urine oxalate to ensure occurrence of hyperoxaluria. Then all groups were fed for 4 weeks according to the following groups:
group 1: Control negative, rats were fed on standard diet.
group 2: Control positive, hyperoxaluric rats kept without any treatment and fed on standard diet.
group 3: Hyperoxaluric rats fed on standard diet replaced with 1.5% khella baladia.
group 4: Hyperoxaluric rats fed on standard diet replaced with 3% khella baladia.
group 5: Hyperoxaluric rats fed on standard diet replaced with 4.5% khella baladia.
group 6: Hyperoxaluric rats fed on standard diet replaced with 6% khella baladia.
At the end of the experiment period, the urine of each rat was collected for 24 hours and it analyzed for determination oxalate, sodium and potassium. Rats were fasted overnight and anesthetized with diethyl ether. Blood samples were collected in clean dry centrifuge tubes from hepatic portal vein; serum obtained by centrifugation was carefully separated for at least 15 minutes at 3000 rpm transferred into clean cuvette tubes and stored frozen at -20°C for biochemical analysis.
At the same time, the organs heart, liver, kidney, spleen and lung were removed washed in saline solution, dried by filter paper and weighted. Biological and biochemical changes were investigated.
The results arrived at revealed the following:
1. The incidence of hyperoxaluria reduced the body weight gain, feed intake as well as the percentage of feed efficiency ratio, it was recovered by feeding the groups with khella powder. The best group was khella baladia 6%.
2. Relative weights of the internal organs increased for hyperoxaluric rats compared to the negative group, but feeding on khella powder treated the enlargement of organs. The best treatment shows a decrease in the maximum relative weights of rats recorded by the sixth group, which contained 6% khella
3. Infection with hyperoxaluria led to an increase in levels of liver enzymes bilirubin fraction, while rats fed with khella powder recorded an improvement in it especially the sixth group (6% khella).
4. Hyperoxaluria led to an increase in serum creatinine, urea, uric acid total protein, albumin and globulin levels. These rates were reduced by feeding the groups on khella powder. The best treatment was recorded for group 6.