الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The concept of nanotechnology was introduced by physics Nobel laureate Richard P Feynman in his famous lecture entitled ‗There is plenty of room at the bottom‘ at the December 1959 meeting of the American Physical Society (Hulkoti & Taranath, 2014). The Birth of modern nanotechnology from the paper in philosophical transactions entitled ‗Experimental relations of gold (and other metals) to light, based on his Bakerian lecture to the Royal Society in London on 5 February 1857, it is clear that Michael Faraday was fascinated by the ruby color of colloidal gold (Faraday, 1857).The world turned its focus towards the use of nanoparticles in the field of drug delivery in 1950‘s and 1960‘s. Prof. Peter Paul Speiser was one of the pioneers who first investigated poly-acrylic beads for oral administration. In 1960‘s first nanoparticles were developed for drug delivery and vaccines. Sugibayashi et al., (1977). Bound 5-flouro uracil to the albumin nanoparticles and observed the denaturation temperature dependent differences in drug release and also distribution of the drug in the body of mice after intravenous tail injection.