الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Atopic dermatitis (AD) is a common, chronic, relapsing,
inflammatory skin disease that primarily affects young children. It
results in significant morbidity and adversely affects the quality of
life.
Although the cause of AD is not fully understood, AD is a
disease that develops as a result of a complex interplay between the
innate and adaptive immune responses, environmental factors, and
activation of keratinocytes which produce various pro-inflammatory
cytokines.
Periostin is an extracellular matrix (ECM) protein belonging to
the fasciclin family, it binds to other ECMs, collagen I, fibronectin,
and tenascin-C, and enhances collagen fibrillogenesis by activating
lysyl oxidase, Periostin is reexpressed in adult life after myocardial,
vascular and skeletal muscle injury and after bone fracture.
Periostin has emerged as a novel mediator in chronic states of
allergic diseases and plays an important role in tissue remodeling in
allergic inflammation.
Periostin has a unique role as an intrinsic mediator in
amplifying and maintaining allergic skin inflammation by linking
Th2-type inflammation and keratinocyte activation, thus, periostin
may be a key molecule in the development of chronicity in AD
inflammation.
The study was conducted on a total number of 80 subjects;
these included 40 patients with AD; childhood phase, beside 40 age
and sex matched healthy subjects as a control group.