الفهرس 
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Abstract
Background : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by a large number of autoantibodies and fluctuating disease activity that results in tissue damage and potentially life-threatening multiorgan failure. Hematological abnormalities are common findings in patients with SLE. Sometimes, hematological abnormalities can be caused by the pathophysiology of SLE itself, but at other times they can be found in patients with SLE but not be a manifestation of SLE. The complement system is an important effector pathway of innate immunity and plays a major role in SLE. Complement participation may occur in at least two ways. One of them is deficit of some components which has been implicated as a risk factor for disease development. The aim of the work : The aim of the present study is to determine the degree to which previous or concurrent changes in complement levels are associated with changes in blood picture in childhood SLE. Type of study : across sectional descriptive and analytical study. Materials and Methods: Fifty pSLE patients (8–18 years of age) were recruited from SLE outpatient clinic and from Mansoura University Children Hospital. All cases included underwent complete history taking and full clinical examination and laboratory investigations including CBC, C3, ANA & anti-ds-DNA, ESR. Results: In our study: There is statistically significant positive correlation between HB level, WBCS count, lymphocytes count, platelet count & C3 level among studied cases. Lymphocyte’s count is a significant predictor of C3 level. Conclusion : measuring complement levels may be considered as a marker for significant changes in blood picture of SLE patients and can help to identify a group of patients who are more susceptible to haematological complications. Recommendations : Results suggest that hypocomplementemia may be associated with changes in blood picture in pediatric patients with SLE so futher studies should be peformed to confirm the relation between them.