الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Evidence declared that the crosslink between immune system and nervous system after peripheral tissue damage implicate in a range of inflammatory responses. Moreover, these responses occur through cellular and molecular events and interactions that efficiently minimize impending injury or infection. In which, the body initiates a chemical signaling cascade and releasing of various mediators to stimulates responses. These mediators activate the primary afferent neurons to enhance nociceptive signal transmission to the central nervous system starting from spinal cord to brain centers. Over and above, there is no doubt that Inflammation is a complex immune response that occurs in reaction to any type tissue damage, (i.e. infection or damage by chemical irritants) that contributes to removing the harmful stimulus and promoting the healing process. At the level of tissue damage, Inflammation not only produces hyperalgesia but also often is accompanied by spontaneous pain (that is pain without any direct sensory stimulation). However, uncontrolled acute inflammation may become chronic, contributing to a variety of chronic inflammatory diseases.