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Abstract Cardiothoracic surgeries are associated with significant pain. Optimal analgesia is a vital part of enhanced recovery after surgery strategies intended to improve patients’ perioperative experience and outcomes. Traditionally, analgesia in these types of surgeries has depended on large doses of I.V. opioids This is particularly pertinent given the current focus on removing needless perioperative opioid administration, and thereby decreasing the potential for opioid side effects. As an alternative, there is a growing appreciation for the critical role that regional anesthesia can play in an overall multimodal anesthetic strategy Among regional anesthesia strategies, techniques involving an injection of local anesthetic into fascial planes. Pectoralis nerve (Pecs) and serratus plane nerve blocks are newer ultrasound (US)-guided regional anesthesia techniques of the thorax. The increasing use of ultrasonography to identify tissue layers and, particularly, fascial layers has led to the development of several newer interfascial injection techniques for analgesia of the chest and abdominal wall. For instance, the Pecs I nerve block was devised to anesthetize the medial and lateral pectoral nerves, which innervate the pectoralis muscles. The aim of the study was to evaluate the effect of postoperative bilateral US guided Pecs block on postoperative pain control in patients undergoing cardiac surgery through mid-line sternotomy compared to systemic analgesia. Approval was obtained from the research ethics committee of Faculty of Medicine; Ain Shams University and a written informed consent was taken from each patient to participate in the study, patients were randomly allocated into two groups with 15 patients in each group. group 1 (control group) received systemic analgesics, whereas group 2 (study group) received pecs block. Our study showed that when compared to general anesthesia with systemic opioids, PECs block is associated with significantly better postoperative pain control. |