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Abstract Ethnophyto-technology is joining the power of ethnobotany with biotechnology. Ethnobotany has assisted the discovery of important medicines. The main objective of the present study is to evaluate the ethnobotanical role, the anticancer potentiality and allelopathy of Tribulus terrestris growing in Egypt. An ethnobotanical survey including twenty informants was applied using an open-ended questionnaire. All informants agreed in plant recognition and mentioned that it occurs in natural fields during summer season. Thirty-five% of the informants mentioned that T. terrestris traditionally is hepatoprotective while 30% stated that it has diuretic activity. Twenty-five % of the informants mentioned that it removes kidney stones and 20% of them claimed that it is analgesic and has aphrodisiac activities that enhance sex hormones. Fifteen percent informed that the species was used as anti-hypertensive, stomachic, urinary antiseptic and antibacterial herb while 10% of the informants mentioned that it is used as antitumor and immunomodulatory. Additionally, through analyzing the information provided by the interviewed persons with respect to the harmful uses of T. terrestris, 95% of the informants mentioned that the plant is a violent species that has the potential to harm livestock, also it diminishes plant biodiversity by invading and crowding out desirable species, leads to soil dryness, consumes large space during vegetative season and affects the soil pH and absorption of minerals. |