الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In view of the biological and therapeutic importance of isatoic anhydride derivatives and amino acids in many scientific fields, we were interested in designing a new family of quinazoline derivatives containing amino acid derivatives, based on isatoic anhydride, which could introduce a new family of peptidomimic (non-peptide derivatives). The aim of this study is tailoring MAO-A inhibitors considering some factors responsible for selectivity against the A isoform which are i) the presence of electron-rich aromatic moieties (e.g. quinazoline moiety) ii) the presence of hydrazido functionality as in case of Iproniazid; iii) the presence of alkyloxycarbonyl methylene group side chain of aromatic system (e.g. Eugenol analog); changing the ester by hydrazido group was also considered.