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Abstract Few studies were interested studying the predictive factors of epilepsy outcome in Egyptian elderly population. This study included 100 subjects aged 50 years or older with epilepsy who were followed up for a period of 6 months. Epidemiological, clinical, neurophysiological, radiological, and laboratory data were collected and analyzed to detect the factors related to the outcome of epilepsy in this group of patients. Patients with medical comorbidities, post stroke epilepsy, history of status epilepticus, focal onset of seizures, poor response to the first AED used, encephalomalacia or temporal pathology at MRI brain, focal or generalized EEG changes (epileptiform discharge or slowing), higher WBCs count, lower Ca or Mg level had significant poor outcome of their epilepsy at follow up. In the other hand, patients with no medical comorbidities, good response to first AED used, normal MRI brain, normal EEG had a significant good outcome at follow up. No relation was found between gender, age, age of onset, family history of epilepsy, seizure precipitants, seizure types, AEDs used, lateralization or localization of lesions in MRI brain or EEG and the outcome of epilepsy in this sample of Egyptian aged population. |