الفهرس 
Pancreatic TumorsOnly 14 pages are availabe for public view
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Abstract
Background: The main acquired risk factors for pancreatic cancer are cigarette smoking (overall relative risk 1 74) and, to alesser degree, environmental tobacco smoke The second most modifiable risk factor of pancreatic cancer is obesity, Obesity [body mass index (BMI) > 30 kb/m2 ] is associated with a 20%– 40% higher rate of death from pancreatic cancer, Meta-analyses have demonstrated associations between both type 1 and type 2 diabetes mellitus and pancreatic cancer, chronic pancreatitis accounts for 5% of pancreatic cancers..
Aim of the Work: The aim of this study is to evaluate the genetic variants of CD133 gene (rs1029728, rs2240688, rs2286455, and rs3130) as possible non-invasive predictive biomarker for Pancreatic cancer in the Egyptian population, this could help to detect the susceptible individuals, diagnose patients earlier and this improve the therapeutic outcome
Methodology: Analysis of data was performed with IBM® SPSS® (SPSS Inc, IBM Corporation, NY, USA) Statistics Version 25 (2017) for Windows In order to verify normal distribution of data the Shapiro-Wilk test was used Demographic data, Age category, gender and smoking were described in terms of count and percentages While Continuous variables such as laboratory investigations were expressed as mean ± standard error (SE) Data were tested for normal distribution using the Shapiro Walk test. Qualitative data were represented as frequencies and relative percentages. Chi square test (χ2) and Fisher exact was used to calculate difference between qualitative variables as indicated. Quantitative data were expressed as mean ± SD (Standard deviation) for parametric and median and range for non-parametric data.
Results: One hundred thirty-three were recruited in the present study consisting of 84 pancreatic cancers and 49 control, 85 men and 48 women The age of all 133 of participants was ranged between 35 and 81 years 75 of participants were smokers while 58 were nonsmokers.
Conclusion: Genetic polymorphisms of the CD133 gene were associated with risk of Pancreatic cancer are three polymorphisms and represented as rs2240688 (TT) (65 5%) vs (44 9%), rs1029728 (AA) (20 2%) vs (2 0%),, and rs3130 (TT) (32 1%) vs (16 3%) Vs control group 2. There is significant increase in rs2240688 (TT), rs1029728 (AG) and rs3130 (TT) with smoking in pancreatic cancer group vs control group.