الفهرس 
Hashimoto’s DiseaseOnly 14 pages are availabe for public view
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Abstract
Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating autoantibodies against thyroid peroxidase and thyroglobulin. Patients require hormone replacement with oral levothyroxine, and if untreated, they can develop serious adverse health effects and ultimately death. There is a lot of evidence that the intestinal dysbiosis, bacterial overgrowth, and increased intestinal permeability favor the HT development, and a thyroid–gut axis has been proposed, which seems to impact our entire metabolism.Aim of the Work: To Study the Correlation of stool lactobacillus acidophilus and leaky gut syndrome in patients with hashimoto thyroditis.Patients and Methods: This was a case control study that was conducted on 60 Egyptian patients that was divided into 2 groups, group 1 that included 30 patients with Hashimoto s thyroiditis first diagnosed or on therapy and group 2 that included 30 healthy subjects as a control All patients were subjected to: Detailed history regards thyroid symptomatology and onset, course and duration of symptoms, drug history and compliance on treatment, full clinical examination (BP, pulse, BMI, Thyroid, Abdominal examination, skin), thyroid antibodies (TPO (anti microsomal) & (anti thyroglobulin), thyroid profile (TSH, FT4, FT3), PCR for lactobacillus acidophilus in stool and zonulin level in serum (marker for leaky gut).
Results: There was high significant statistical difference found between two groups regarding FT4 being higher in the control group and TSH being higher in the patient group. There was high significant statistical difference found between two groups regarding Anti tpo, Zonulin and Lactobacillus PCR being higher in the patient group. IN the patient group,There was high significant statistical difference found between two groups of present and not present lactobacillus PCR regarding Anti tpo being higher in the present lactobacillus PCR group, and there was high statistical significant difference found between two groups of present and not present lactobacillus PCR regarding Zonulin, being higher in the present lactobacillus PCR group
Conclusion:patients with hashimoto thyroiditis commonly associated withbacterial overgrowth which in term increase the incidence of leaky gut with the zonulin level and the lactobacillus in stool.