الفهرس 
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Abstract
Summary
Vitiligo is an acquired skin pigmentation disorder, which can affect any part of the skin, hair, eyes, and mucus membrane. It is an autoimmune process, which causes the destruction of melanocytes leading to depigmentation of the skin. The rate and extent are variable and unpredictable.
It is a multifactorial polygenic disease and its exact cause remains unknown. Many theories have been developed to explain the mechanisms of melanocytes destruction. These theories include autoimmune mechanisms in the humoral and cellular immunity, cytotoxic, intrinsic, oxidant, and neural mechanisms. The prevalence of vitiligo is estimated to be 0.06-2.28% worldwide.
Utilization of non-invasive biomarkers has become the recent attitude in most of chronic diseases because these biomarkers are affordable and less annoying for the cases.
Mitochondrial fission is mediated by Dynamin-related Protein 1 (DRP1), which is regulated by phosphorylation of DRP1 and acetylation and S-nitrosylation. The fission process is the division of mitochondria into smaller ones, and helps in sorting damaged or impaired mitochondria that are further eliminated by a mitophagy.
This study was conducted to estimate tissue level of mitochondrial dynamic – related Protein 1 in vitiligo & detection of correlation between tissue level of DRP 1 & development of vitiligo.
This case control study included 25 vitiligo patients and 25 age and sex matched healthy subjects as a control group selected from Dermatology outpatient clinic at Beni-Suef University hospital.
After obtaining a written informed consent, the cases were subjected to full history taking and clinical examination including general examination and full dermatological examination.
The assessment of disease severity was conducted by using Vitiligo Area Severity Index.
Assessment of tissue level of DRP1 levels in the skin was conducted by using real time polymerase chain reaction technique.
The results of this study showed that:
• There was no statistically significant difference between the two groups in the basic data including age and sex distribution.
• The course of the disease showed progressive course in all the cases.
• There was 20% with the cases with positive family history.
• The mean VASI score in cases with vitiligo is 2.6 ± 4.5 with range between 0.5 and 20.
• The focal type of vitiligo in the included cases in 7 cases (28%) and acral types that was present also in 7 cases (28%).
• The most affected side were both the upper limbs and the lower limbs (60%) followed by the face (40%).
• The mean level of DRP1 levels in the skin in the cases group was statistically significantly higher as compared with the control group.