الفهرس 
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Abstract
SUMMARY
A
lopecia areata (AA) is a type of non-scarring patchy loss of hair in hair-bearing areas including scalp. It is an autoimmune disease wherein immune response is directed towards self-antigens in a particular organ, primarily mediated by the T lymphocytes causing inflammation around growing hair follicles and characterized by production of cytokines.
Vitamin D, a steroid hormone, has been traditionally considered as a key regulator of bone metabolism, and calcium and phosphorous homeostasis through a negative feedback with the parathyroid hormone (PTH). However, during the last 20 years, the role played by vitamin D has been largely revised by recognizing its pleiotropic action on a wide spectrum of systems, apparatuses and tissues. Thus, vitamin D has growingly been involved as a primary determinant of biological modifications and specific clinical conditions.
Our study aimed to assess the level of (1.25OH vit D) in alopecia areata patients.
Current study was prospective case-control study, it enrolled 50 patients suffering from alopecia areata & 50 healthy participant as control group, all participants were selected from the outpatient clinic of Dermatology, Andrology and Venerology department of Beni-Suef University Hospital.
The relationship between serum vitamin D level and patients’ gender is a matter of debate.
We found a highly significant relationship between vit D level and AA (P=.0001) as Vit d in patient group was (2.1 – 18) with mean (8.39± 4.38), that was lower than control group (7.2– 37.1) with (37.1± 20.437) mean value.
Our study concluded that, 1.25 OH vit D level was lower in patient with alopecia areata than normal population with a highly significant relationship between vit D level and AA.
There was no statistically significant correlation between age and 1.25OH vit D.