الفهرس 
Hepatitis C and Liver CirrhosisOnly 14 pages are availabe for public view
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Abstract
was statically significant Positive correlation Between DKKA1(pg/ml), WBCs and AST. Serum DKK1 was significantly higher in HCC group comparing with liver cirrhosis group and control group. According to our study, ROC curve showed that the best cut off point of DKKA1 to detect Liver Cirrhosis group was > 264.9 pg/ml with sensitivity of 56.67%, specificity of 86.67%, PPV of 81.0%, NPV of 66.7%. Another ROC curve showed that the best cut off point of DKKA1 to detect HCC group was found > 453 with sensitivity of 83.33%, specificity of 93.33%, PPV of 92.6%, NPV of 84.8%. Assessment of diagnostic performance of serum DKK1 when used in discriminating group (HCC) from group (Liver Cirrhosis), revealed a better diagnostic performance of DKK1) as the best ROC cut-off for DKK1 was > 1674.8 ng/mL, this had a diagnostic sensitivity of 50%, specificity 96.67%, positive predictive value 93.7%, negative predictive value 65.9%. Conclusion: In conclusion, our study suggests that DKK-1 may be a key regulator in HCC progression, a promising potential therapeutic target for HCC. We also demonstrated that serum DDK-1 could be a useful marker for diagnosing HCC.