الفهرس 
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Abstract
Atherosclerosis is characterized by thickening, hardening and decreased elasticity
of the arterial wall. Lipid levels, endothelial cell injury, inflammation and the migration
of vascular smooth muscle cells (VSMc) are considered as several fundamental
pathological processes of atherosclerosis. Previous evidence suggested that TSP-1 can
interact with some of the aforementioned factors and further regulate the pathological
process of atherosclerosis through various mechanisms.
The purpose of this study was to evaluate serum levels of Thrombospondin-1 in
patients as regards presence and /or absence of coronary artery disease and type 2 DM
and their influence on serum Thrombospondin-1 levels and their distribution in subgroups
of patients were assessed.
180 individuals were enrolled, divided into four groups; group I (n = 44 patients):
non diabetic subjects without CAD, group II (n = 40 patients): diabetic patients with
non CAD, group III (n = 49 patients): non diabetic patients with CAD, group IV (n =
47 patients): diabetic patients with CAD.
Participants in the study were subjected to history taking, through clinical
examination, 12 leads ECG.
2D echocardiography, M-mode were performed;LA diameter and LV dimensions
were measured including LVEDD, LVESD, IVSD, LVPWD, LVMI and left ventricular
ejection fraction.
Serum Thrombospondin-1 levels were measured in addition serum creatinine,
blood urea, serum glucose (fasting and post prandial, HBA1C), hs CRP and lipid profile
were measured to all patients.
Coronary scoring was done to all patients using vessel, severity, gensini’s and
syntax scores.
Results of the current study showed that:
*Demographic and clinical data:
Age:
The mean age for group I (control group) was 53.91 ± 7.10 years,the mean age
for group II was 53.50 ± 7.27 years and the mean age for group III was 54.96 ± 8.04
years, the mean age for group IV was 57.53 ± 6.43. There was statistical significant
difference between all studied groups as regard age (p-value < 0.05).
Weight:
The mean weight for group I (control group) was 75.93±5.84, the mean weight
for group II was 78.75±5.68 , the mean weight for group III was 81.14±5.68 and the mean
weight for group IV was 85.72±7.40. There was statistical highly significant difference
between the 4 groups as regard weight (p-value < 0.001).
Clinical data:
There was highly significant difference between all studied groups as regard HTN, and smoking (p- value < 0.001).
* Echocardiography data:
There was a significant difference between all studied groups as regards
echocardiographic parameters IVS, LA , LVmass , LV mass index (P-value < 0.05).
There was highly significant difference between all studied groups as regards
EF,FS (P-value < 0.001) but no significant difference as regards LVEDD ,LVESD ,PW , PASP (P-value > 0.05).