الفهرس 
Definition of obesityOnly 14 pages are availabe for public view
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Abstract
Obesity refers to the increase of excess body fat due to an energy imbalance. When energy intake exceeds energy expenditure, the surplus energy is stored in the body in form of fat, leading to adipose tissue enlargement, dyslipidemia, and fatty liver, and is linked to other metabolic diseases such as diabetes mellitus, cardiovascular disease (CVD), and certain types of cancer.
Some nutritional mixtures affect the treatment of obesity such as soybean, coffee, and oat declare that caffeine and chlorogenic active compounds in coffee that help improve and reduce body weight gain and coffee had an anti-effect of obesity.
Soybean affects obesity by lowering body weight, fasting blood glucose levels, and hepatic fat accumulation. Soybean polysaccharides and genistein prevent high fat-induced body weight gain, dyslipidemia, oxidative stress, and inflammation.
consumption of oat reduced body weight, BMI, body fat. AST and ALT both showed decrements in patients with oat consumption, and researchers concluded that consumption of oat reduced obesity.
Mesotherapy is a medical technique developed in 1952 by the renowned French physician Dr. Michel Pistor for the management of pain and vascular disorders in France. Mesotherapy injection contains many ingredients that have an effective role in the treatment of obesity such as aqua, soybean extract, deoxycholate, carnitine, Cynara scolymus, leaf extract, organic silicon, caffeine, and theophylline.
The term ”mesotherapy” is derived from the Greek words ”mesos” meaning ”middle” or ”mean” and ”therapeia” meaning ”to treat medically” i.e., injecting in to the middle layer of skin or ”intradermotherapy”.
The depth of penetration of the needle should not exceed 4mm for it to be effective.
The Study plan:
The main materials used in this study were mesotherapy injection called meso shape obtained from Meso Static Company, and natural product (coffee, soybean, and oats as powder) obtained from authorized suppliers in Egypt. These natural products have been mixed in equal proportions at room temperature.
Experimental animals:
All rats were fed on basal diet for one week for adaptation, then the rats were divided into two main group:
• The first main group (n = 6): weighing 120±5 g rats, were fed on the basal diet as negative control.
• The second main group (n = 30): weighing 220+-20 g (obese rats). The obese rats were divided randomly into five subgroups (6 rats each) according to the following
- Subgroup (1) Rats were fed on the basal diet as a negative control.
- Subgroup (2): Obese rats were induced by fed on high fat diet (20% animal lipid) and used as a positive control group.
- Subgroup (3): group obese rats were fed on plants mixture by 2% of the weight of the diet.
- Subgroup (4): group obese rats were fed on plants mixture by 4% of the weight of the diet.
- Subgroup (5): group obese rats were treated with 2.5 ml mesotherapy injection
- Subgroup (6): group obese rats were treated with 5 ml mesotherapy injection:
The experiment took 28 days, at the end of the experimental period each rat weight separately then, rats are slaughtered and collect blood samples to perform the following tests: lipid profile, liver function and kidney function, extracting the liver, kidney and heart for weight.
The obtained results can be summarized as follows:
1- feeding rats with 4% of mixture herbs was more effective (P 0.05) in reducing LDL, T.B and T.C than rats feeding with 2% of mixture herbs. The data also showed injection rats by 2% of mesotherapy and injection rats by 4% of mesotherapy had given the same result in HDL. Injection rats by 4% of mesotherapy was more effective (P 0.05) in reducing LDL, VLDL, AI, T.G and T.C.
2- no significant (P 0.05) in VLDL and AI between rats feed by 2% mixture of herbs and rats feed by 4% mixture of herbs. Feeding rats with 4% of mixture herbs was more effective (P 0.05) than feed rats with 2% of mixture herbs in LDL, T.G and T.C.