الفهرس 
Major Depressive DisorderOnly 14 pages are availabe for public view
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Abstract
Background: Patients afflicted with depression show different clinical manifestations and clusters of symptoms e.g., vegetative and psychomotor symptoms. Attention has recently focused on the inflammatory nature of depression. A cross-sectional comparative study was conducted to assess the relationship between C-reactive protein (CRP) level and between depression symptom profile, severity, associated anxiety and somatic symptoms.
Method: 120 patients with depression were enrolled. Full history including socio-demographic data, medical, psychiatric and family history as well as mental status examination were done, then SCID-1, Beck Depression Inventory II, Hamilton Anxiety Rating Scale, Somatic Symptom Scale 8 were applied. Quantitative high sensitive C-reactive protein was measured in all patients.
Results: CRP was significantly positively correlated with number of episodes (P = 0.006) and duration of illness (P = 0.15). It was also significantly positively correlated with BDI-II psychomotor in the severe BDI-II group (P = 0.024).
Conclusion: There is a positive correlation between CRP level and between duration of illness and number of episodes of MDD. Also there is a positive correlation between CRP level and between psychomotor symptoms in patients with severe MDD.