الفهرس 
Urinary tract infectionOnly 14 pages are availabe for public view
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Abstract
Urinary tract infections (UTIs) are the foremost common bacterial infections in
pregnant women. Complications that result in significant morbidity and mortality in both
the fetus and also the mother could also be limited by early and proper management.
urinary tract infection in pregnancy if untreated on time or inefficiently treated it’s going
to result in severe maternal and fetal complications. Therefore, all pregnant women
should be screened a minimum of once by urine culture for lower urinary tract infections
throughout their antenatal controls, during early pregnancy, if possible. Pregnant women
should be treated if the results of urine culture are positive.
We divided the pregnant women three equal groups:
group (I): Includes 40 patients with uncomplicated lower urinary tract infection
in pregnancy and received one sachet of 3g Fosfomycin tromethamine
(Monuril®) on 150ml water on empty stomach before dinner orally.
group (II): Includes 40 patients with uncomplicated lower urinary tract infection
and received 100mg Nitrofurantoin (Uvamine retard®) three times daily orally
for 7 days
group (III): Includes 40 patients with uncomplicated lower urinary tract
infection and received 500mg Cephalexin (Keflex®) three times daily orally for
7 days.
The aim of this study was to compare the efficacy (clinical and microbiological)
and safety of single-dose of Fosfomycin tromethamine (Monuril®) administered orally
to treat lower urinary tract infections in pregnant women compared to Nitrofurantoin
(Uvamine retard®) three times daily for 7 days and compared to Cephalexin (Keflex®)
three times daily for 7 days.
We found the clinical cure rate was 96.5% in Fosfomycin group, 93.75% in
Nitrofurantoin group and 88.5% in Cephalexin group.
We found the microbiological cure rate was 95% of cases have taken singledose
of three g Fosfomycin were cured. The second group who has taken seven days
course of Nitrofurantoin, only 92.5% were cured. The third group who has taken
seven days course of cephalexin, only 90% were cured.
The three drugs were tolerable orally and there were no statistically significant
differences between the three studied groups as regard to side effects of the drug with
Fosfomycin group, nitrofurantoin and cephalexin groups (20% vs 37.1% vs 40%
respectively).
After the study and according to our results we concluded that single-dose of
three g Fosfomycin was as effective as 7 days course of Nitrofurantoin and seven days
course of Cephalexin treatment.