الفهرس 
EpilepsyOnly 14 pages are availabe for public view
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Abstract
Epilepsy is one of the most common serious neurological disorders.
The definition of epilepsy requires the occurrence of at least two or more
unprovoked seizures occurring at an interval greater than 24 hours apart.
Children with epilepsy, particularly infants, differ from adults not only in
the clinical manifestations of their seizures, but also in the presence of
unique electroencephalogram (EEG) patterns, etiologies, and response to
antiepileptic drugs. The immature brain, particularly in the neonate and
young infant, differs from the adult brain in the basic mechanisms of
epileptogenesis and propagation of seizures. It is more prone to seizures,
but seizures are more apt to disappear as the child grows.
Serum amyloid A (SAA) protein is a type of apolipoprotein that
binds to high-density lipoprotein in the serum. During inflammatory
diseases, SAA was secreted into the plasma and has been used as the
acute-phase marker, together with other reactive proteins. It showed some
superior characteristics in clinical diagnosis in compared with C-reactive
protein, for example, in terms of sensitivity.
The current study aimed to investigate the human serum amyloid
A protein changes in children with 1st attack of epilepsy and epileptic
children on treatment.
This study was conducted on 95 children recruited from Pediatric
Neurology outpatient clinic, Faculty of Medicine, Menoufia University
after obtaining consent their parents and care givers during the period
study from September 2018 till June 2020.
The studied patients were classified into:
group I: consisted of 40 Children with first attack of epilepsy.
group II: consisted of 40 epileptic children controlled by treatment.
group III: (Control group) apparently normal 15 children of matched
age and sex served.
Children with seizures were determined according to the guidelines
of the International League Against Epilepsy.
Inclusion Criteria:
Children with seizures presented within 24 hours‘ postictal state.
Age: 6 months -16 years.
Both sexes.
Exclusion Criteria:
Any patients with severe liver/kidney dysfunction, heart disease,
lesion or malignant disorders, cancer, psychiatric patients.
Any patients undergoing medication that affect serum amyloid other
than antiepileptic drugs in past 2 weeks before admitting into the
hospital.
All Patients and controls included in the study were subjected to
the following:
1. Written or informed consent from their parents and care givers.
2. Full history taking
3. Full clinical examination focusing on neurological examination.
4. Routine laboratory investigations: including CBC, Kidney function,
Liver function, Serum electrolyte.
5. Imaging: EEG, CT, and MRI when needed.
6. Serum amyloid A protein changes level (SAA) using Human SAA
ELISA kit.