الفهرس 
Febrile SeizureOnly 14 pages are availabe for public view
 |  | from | 67 |  |  |
| | | from | 67 | | |
Abstract
Febrile seizures are the most common form of seizures in children (2% to 5%),
with a peak prevalence during the second year of life. They occur in febrile infants with
no history of spontaneous seizure or neurological insults. Studies suggest that fever
leads to enhanced neuronal excitability and lowers the seizure threshold.
The genetic contribution to the incidence of febrile seizures is manifested by a
positive family history for febrile seizures in many patients. In some families, the
disorder is inherited as an autosomal dominant trait, and multiple single genes that cause
the disorder have been identified in such families. However, in most cases the disorder
appears to be polygenic, and many genes predisposing to it remain to be identified.
Genes associated with febrile seizures include sodium channel genes; SCN1A, SCN1B,
SCN9A, and CPA6.
A single Nucleotide Polymorphism (rs689466) localized at 5′-1192 of
the PTGS2 gene exhibited significant association with FS (p = 0.045) based on casecontrol
allelic association analyses.
The current study aimed to investigate Prostaglandin S2 (rs689466) single
nucleotide polymorphism in children with febrile seizure. It was conducted on 50
children represented in emergency room or pediatric department, Menoufia University
according to criteria of febrile seizure started February 2020 till February 2021.
Patients were divided into two groups:
A- Patient group (group 1): Include 35 child with typical and atypical (complex)
febrile seizure.
B- Control group (group 2): 15 apparently healthy children at same age, sex
group and socioeconomic state.
Inclusion criteria:
1- Both Sex.
2- Age: 6 months to 5 years.
3- Children with simple and complex febrile seizure fulfilling the following
criteria:
A simple febrile seizure is a primary generalized, usually tonic-clonic, attack
associated with fever, lasting for a maximum of 15 min, and not recurrent within a 24-hr
period.
A complex febrile seizure is more prolonged (>15 min), and/or is focal, and/or
recurs within 24 hours. Most patients with simple febrile seizures have a very short
postictal state and usually return to their baseline normal behavior and consciousness
within minutes of the seizure
Exclusion criteria:
1- Seizure caused by CNS infection or brain malformation.
2- Children with inborn error of metabolism.
3- Children with developmental delay or chromosomal anomalies.