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Abstract Herpes zoster (HZ) is the reactivation of the Varicella Zoster virus (VZV) which accesses the sensory ganglia during primary infection and typically causes painful skin lesions. Although the vesicular rash disappears after a few weeks the pain may persist, resulting in post-herpetic neuralgia (PHN) Acute severe pain and PHN are feared complications of HZ infection The pain lasting for the first 30 days is known as acute herpetic neuralgia. More the severity of acute pain, the greater is the risk of developing PHN When the pain persists beyond 90 days after the onset of rash, it is termed PHN. If an appropriate degree of pain reduction is not established in the acute phase of HZ, the risk of PHN development is increased . |