الفهرس 
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Abstract
English Summary
Due to the high biological properties of many condensed pyrimidines such as pyrazolopyrimidine derivatives as pharmacophores in drugs synthesis aslo the diversity of biological & physiological activities of several organic sulfer heterocycls such as thiazoles, thiazolienes and thiazolidienes, which exhibit pesticidal, herbicidal, fungicidal, antiviral, antiprotozoal and hypo-glycemic activity, attributed to the presence of the NCS fragment. So our aim is the synthesis of new derivatives of such compounds class. Attachment of such heterocyclic system is expected to result in the formation of products of great interest. Evaluation of these compounds for their biological activity as anticancer agents will be reported.
Plan of the work:
1. Synthesis of novel substituted pyrazole ring system with free amino group in position 5.
2. Heterocyclization of the prepared pyrazole derivative to the pyrazolopyrimidine condensed ring system.
3. Study of the reaction of some of the synthesized derivatives with haloester followed by hydrazine hydrate to form the corresponding hydrazide derivatives.
4. Heterocyclization of the resulting acid hydrazide derivatives with different reagents.
5. Glycosylation of the resulting functionalized pyrazolopyrimidines and oxadiazole derivatives.