الفهرس 
Defintion of hyperlipidemiaOnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
Nutrition plays a vital and important role in human health and the maintenance of body weight gain, which can be risky health condition. That a third of the world’s population is hyperlipidemia ,it is one of the greatest risk factors contributing to the prevalence and severity of coronary heart diseases stroke, atherosclerosis and hyperlipidemia are the primary cause of death. Hyperlipidemia is characterized by elevated serum total cholesterol (TC), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) and decreased high density lipoprotein (HDL) levels.
Among these, hypercholesterolemia and hyper triglyceridemia are closely related to heart disease here show the importance of powder leaves of both Annonasquamosa and Citrus aurantifolia in helping to reduce hyperlipidemia , because it which contains several medicinal properties and anti-oxidants . anti-oxidants are the compounds responsible for the protection of living organism from the damage caused by the abnormal production of reactive oxygen species concomitant lipid peroxidation, protein damages and others including DNA strand breaking (the enzymes catalase, superoxide dismutase and glutathione ). Contains also active phytochemical substances as follows: flavonoids , phenols, and limonoids .This is one of the qualities that qualify to reduce hyperlipidemia therefore it was used in this study as a tool to treat the problem of hyperlipidemia .
7.1 Active compounds
Determination of Total phenols, total flavonoids and antioxidan activity
contents of the Annona squamosa and Citrus aurantiifolia leaves.
Identified of phenolics compounds in annona leaves and Citrus
aurantiifolia leaves by HPLC.
7.1.1 Determination of total phenols, total flavonoids and antioxidan
activitycontents of the leaves .
• The results indicated that total phenols and total flavonoids recorded the lowest level in Annona quamosa leaves while Citrus aurantifolia leaves was the highest .
• The results indicated that antioxidan activity contents recorded the highest in Annona quamosa leaves while Citrus aurantifolia leaves was the lowest
7.1.2. Identified of phenolics compounds in annona leaves by HPLC
• The highest values of phenolic compounds in the leaves of the Annona quamosa recorded hydroxy benzoic acid.
• The lowest values of phenolic compounds in the leaves of the Annona quamosa recorded Syringic acid .
7.1. 3 . Identified of phenolics compounds in Citrus aurantiifolia leaves by HPLC.
.
• The highest values of phenolic compounds in the leaves of the Citrus aurantiifolia recorded Pyrogallol acid.
• The lowest values of phenolic compounds in the leaves of the Citrus aurantiifolia recorded Gallic acid .
7.2 Experimental animals
Forty female albino rats, sprague dawley strain, weight 120 ± 10g .The animals were classified in to 8 equal group (5rat in each group)
7.2.1 Experimental design
7.2.2. The induction of experimental hyperlipidemia
Hyperlipidemia was induced in normal healthy immature female albino rats by10% animal fat for 28 days where replacing the proportion of fat or corn oil in the standard meal saturated fats (lamb) and treated during the duration of the experiment .
4..2.3 Experimental design
All groups of rats were fed on the experimental diet for 28 days according to the following groups:
Rats were randomly divided into two main groups.
The first group,negative control group (n=5), Fed standard diet only
The second main group Hyperlipidemic rats (n=35).
Hyperlipidemic rats were divided into 7 groups(5in each group) according to the following groups:
group (1): positive control,fed fed hyperlipidemia diet only.
group (2): fed hyperlipidemia diet and 2.5%of Annona squamosa leaves powder.
group (3): fed hyperlipidemia diet and 5%of Annona squamosa leaves powder.
group (4): fed hyperlipidemia diet and 7.5%of Annona squamosa leaves powder.
group (5): fed hyperlipidemia diet and 2.5%of Citrus aurantifolia leaves powder.
group (6): fed hyperlipidemia diet and 5%of Citrus aurantifolia leaves powder.