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Abstract The current study depended on two ep idemiological datasets: A. The first LSD dataset was obtained from a cross-sectional serop revalence study carried out during the p eriod from March 2018 to November 2018. A total number of 665 animals (599 cattle and 66 buffa lo ) of different ages with a history of vaccination of a majority of animals (n=651) by the sheep p ox vaccine from different five localities (El-kh a n k a, Benha, Qalyub, El-Kanater El-Khayria, and Qaha) in El-Qalyubia governorate were examined to study the serop revalence of LSD in El- Qalyubia governorate and to ass ess some risk factors (animal sp ecies, animal age, immune status, seasonality, temperature-humidity index (THI), and locality) associated with LSD infection in cattle and buffalo. In this regard three different statistical models were ap plied to this data: 1. Chi-square test for indep endence: was ap p lied to assess if or not there was an association between each of the animal p rofile variables (animal sp ecies, age, immune status, seasonality, THI, and locality) and t h e p revalence of LSD. The results of that univariate analysis demonstrated that animal sp ecies, age, and locality were p otential risk factors significantly associated with LSD infection. ✓ In conclusion: ❖ Although the Chi-square test of indep endence is a tr a d itio nal o ld model used for assessment of the disease’s associated ris k fa ct o rs dep ending only on the differences between the o b s er v ed a n d t h e exp ected frequencies with no resp ect to the data distribution, it gives reasonable results with a large size dataset. |