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Abstract Summary olycystic ovary syndrome (PCOS) is a complex disorder with mul brtisystem b involvement. In addition to ovulatory dysfunction, dysregulated androgen biosynthesis, increased risk of insulin resistance (IR), Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of brreproductive age with primary manifestations of infertility, menstrual dysfunction, obesity and clinical orr>biochemical hyperandrogenism (hirsutism, acne and elevated androgen). Polycystic ovary syndrome affects about 7 to 8% of women and may be the most common cause of anovulation, early pregnancy loss, and later pregnancy complications. All have been implicated in the low fecundity of women with this disorder. Insulin resistance (IR) has been considered to be the most important etiological aspect of the reproductive and metabolic abnormalities in PCOS. Recently, the role of adipose tissue hormones, particularly adiponectin has been implicated in the pathogenesis of PCOS. Adiponectin has antiatherogenic, antidiabetic, anti-inflammatory and insulin sensitizing effects, and is negatively related to the degree of adiposity in healthy individuals. Studies have shown that adiponectin has beneficial effects on the reproductive processes and an important relationship with the gonadotropins and other hormones. Studies have also shown that both insulin action and circulating levels of adiponectin are lower in women with PCOS. The aim of this study was to evaluate the level of serum adiponectin in polycystic ovarian syndrome (PCOS) and the potential use of adiponectin as a biomarker for PCOS and to compare adiponectin levels in women with |