الفهرس 
Heterocyclic compoundsOnly 14 pages are availabe for public view
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Abstract
A number of a new synthesized steroidal heterocyclic compounds are
produced due to the combination between estrone and different heterocyclic
substituents. The structures of all synthesized compounds were approved by
their spectral and analytical data; IR, 1HNMR and Mass spectra which are all
agreed with the assigned structures. The designed compounds were evaluated as
anti-cancer agents against MCF7, PC3 and HepG2 cancer cell layers.
When estrone (1) was allowed to react with benzaldehyde, 4-
fluorobenzaldehyde or 4-methoxybenzaldehyde and thiourea in boiling ethanol,
it afforded compounds 2a, 2b and 2c which were reacted with equimolar
amount of phenacyl bromide in refluxing absolute ethanol to produce
compounds 3a, 3b and 3c (Scheme 1).