الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 138 |  |  |
| | | from | 138 | | |
Abstract
Psoriasis is a chronic immune-mediated inflammatory disorder characterized by abnormal proliferation of epidermis, inflammation and angiogenesis in dermis and is associated with several comorbidities and significantly diminishes patients’ quality of life. Psoriasis affects about 2.3% of the world’s population. Psoriasis is no longer considered to be entirely a skin disorder, since there is considerable evidence supporting the idea of being a systemic inflammatory disease.
Psoriatic lesions are of diverse shapes; well-defined, red and somewhat raised plaques with silver-whitish scales,the scales are lightly attached and can be easily peeled off, on peeling several layers at once, pinpoint bleeding can occur.
There are five main types of psoriasis; plaque,guttate,pustular and erythrodermic type. The most common form is plaque psoriasis that occurs in about 90% of patients and most commonly affected areas are back of the forearms, shins, navel area and scalp.
Long Non– Coding Ribonucleic Acid are defined as the transcripts of more than 200 nucleotides that structurally resemble mRNA but do not encode proteins. lncRNAs participate in a variety of biological processes, such as chromosome imprinting, epigenetic regulation, cell-cycle control, transcription, translation, splicing, and cell differentiation.
The LncRNA GAS5 is a 5′-terminal oligopyrimidine class of genes which regulates cell growth, proliferation and survival.