الفهرس 
Cancer
Structure, function and signaling of PTENOnly 14 pages are availabe for public view
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Abstract
The chemotherapeutics that have anti-tumor activity suffer from both toxicity and intolerability if used for long time. Thus, there has been an increased interest to identify novel combined agents with effective, non-toxic,
inexpensive, and suitable adjuvant therapy with Doxorubicin (DOX) to decrease its dosage and adverse effects without lowering its therapeutic efficacy. Thus, the goal for new drug combinations that can increase or sustain
effectiveness, minimize toxicity, and postpone drug resistance growth is essential. Also, this study aims to evaluate the synergistic chemo-preventive and
anticarcinogenic activity of the combinations of Chloroquine (CQ) and /or Tioconazole (TIC) targeted therapy with/without DOX in vitro and in vivo models. The main goal was to investigate the putative underlying mechanisms
of crosstalk of proliferation, autophagic and apoptotic machinery in cancer cells that treated with DOX with CQ and/or TIC. Therefore, we hypothesized that CQ/TIC combination can be used as adjuvant to DOX to improve its therapeutic efficacy; improve drug resistance
and reducing its adverse effects.To achieve this purpose the following experiments were carried out:In Vitro Study:
1. Cytotoxicity test of CQ/TIC combined with DOX were performed
against cancer cell lines.
2. Combination activity of CQ/TIC combined with DOX was carried out by using compusyn program; The effect of tested drugs combinations on MCF- 7 cell line was carried out by using nonconstant ratio as fractions from IC50 of each one of the these drugs.