الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
The human genome is composed of deoxyribonucleic acid (DNA), which is the heritable macromolecule that carries the information essential for life. The DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made of double strand DNA that tightly coiled several times around proteins called histones which support its structure.
Diabetes Mellitus (DM) constitutes one of the most serious global health problems of the twenty-first century. It is a chronic, progressive and serious disease. DM disturbs the body organs and occurs when the pancreas cannot secrete enough insulin or the body can’t use the available insulin efficiently.
Recently, the relationship between cancer and diabetes is greater than expectations. Different studies have demonstrated that patients with diabetes who needed surgery or chemotherapy are exposed to higher rate of death.
Genotoxicity indicates the ability of the substance to impair different cellular components as spindle fibers, DNA polymerases, DNA repair system. As well as cytotoxicity means a potential cell death. Sitagliptin is dipeptidyl peptidase-4 (DPP-4) inhibitor. It is used in treatment of type II DM. Oral DPP-4 inhibitors are widely used because of their effects on lowering hemoglobin A1C, without weight gain and hypoglycemia risk. Sitagliptin is a promising anti-diabetic drug so it should be well evaluated regarding its genotoxic and cytotoxic effects for better evaluation of management plan.
This work was designed to evaluate the genotoxic and cytotoxic effects of the antidiabetic drug (Sitagliptin) in human lymphocyte culture.