الفهرس 
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Abstract
Appropriate treatment and wound care accelerate the healing process and prevent infection and chronicity of the wound. Different methods and approaches have been used to achieve shorter wound healing times. Despite extensive efforts to improve wound healing, the outcomes of existing methods are far from optimal. One such agent that has been tried in wound healing is phenytoin. Phenytoin (diphenylhydantoin) was introduced into therapy in 1937 for the effective control of convulsive disorders. A common side effect with phenytoin is the development of fibrous overgrowth of gingiva .This apparent stimulatory effect of phenytoin on connective tissue suggested an exciting possibility for its use in wound healing. Light-emitting diode (LEDs) have a promising prospect because of its outstanding advantages: 1) long lifetime, 2) environmentally friendly, 3) flexibility of color mixing, 4) high illumination efficiency, etc. Based on the electrical characteristics of LEDs, a constant current driver is needed to support the LED working performance. With the wide applications of LEDs, many new technologies are presented. The possible mechanism of action by which phenytoin promotes wound healing has beencontribute to increase in the proliferation of fibroblasts hence increase in the deposition of collagen, increase in Neovascularisation enhanced granulationtissue formation. A decrease in the action collagenas and decrease in bacterialcontamination that may be a primary antibacterial effect of phenytoin or if it is due to a secondary effect of phenytoin, such as neovascularisation and/or collagenisation and there has been at least one study which refutes its beneficial healing effect. Low level light therapy has a significant influence on a variety of cellular functions. Increased mitochondrial respiration and adenosine triphosphate (ATP) synthesis, cell proliferation, enhancement, and promotion of tissue regeneration following injury. Stimulation of cell proliferation results from an increase in mitochondrial respiration and ATP synthesis. It is assumed that this absorption of light energy may cause photodissociation of the inhibitory nitric oxide, leading to the enhancement of enzyme activity, increased electron transport, oxygen consumption, mitochondrial respiration, and ATP production. In turn, LLLT, by altering the mitochondrial or cellular redox state, can induce the activation of numerous intracellular signaling pathways and alter the affinity of transcription factors concerned with cellular migration, proliferation, survival, tissue repair, and regeneration. Our results indicated that non-coherent LED light had better stimulatory effects when combined with phenytoin and was superior to it when used alone. On the cellular level, LED light modulates fibroblast proliferation, increases collagen bond and synthesis, promotes angiogenesis, improves energy metabolism and produces biological effects during the healing phase.. The combined phenytoin and LED light have a positive healing effect on dorsal mice wounds regardless of the radiation dose. LED light was considered more effective compared to phenytoin in terms of fibroblast proliferation and collagen fiber density. However, further randomized clinical studies are required to determine the effect of combination of these two modalities of therapy on wound healing in humans.