الفهرس 
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Abstract
Summary
Vitiligo is a relatively common pigmentation disorder in which the skin melanocytes are lost or destroyed.
Exosomes are cell-derived vesicles which deliver various bioactive molecules including RNA molecules which may serve as potential diagnostic paracrine biomarkers in molecular medicine
Long non coding RNA H19 (H19) was supposed to play a role in melanogenesis and melanocyte cell survival. H19 downregulates the expression of p53 and subsequently vital genes in melanocytes.
H19 acts as an important regulator for Let-7a. Let-7a plays a role in melanin metabolism, oxidative stress response and apoptosis.
This study was performed to clarify the suggested paracrine role H19 and Let-7a derived from human skin exosomes in the pathogenesis of vitiligo vulgaris.
The study included 50 vitiligo vulgaris patients, and 50 healthy volunteers serving as controls. 4 mm punch skin biopsies were taken from all subjects. Skin biopsies were examined for H19 and A Let -7a genes expression using RT-PCR technique.
The expression of H19 and Let-7a in vitiligo lesions (1.736±0.84 and 6.07±2.26 pg/mg, respectively) was significantly higher than their expression in controls (0.8462±0.3483 and 1.514± 0.9202 pg/mg respectively) (P< 0•001). A moderate positive correlation was found between the expression of H19 and the disease activity with (P-value 0.0382).
Additionally positive correlation between the expression of Let 7a and the disease duration was found with (p value 0.0306).
We can conclude that up regulation of H19 and Let-7a genes expression could describe their possible role in the pathogenesis of vitiligo.