الفهرس 
Acknowledgement
Risk Factors for breast cancerOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most common malignancy in women around the world. Breast cancer is a heterogeneous disease, and thus the risk of recurrence can differ significantly between patients. Biological factors have predictive and prognostic value in breast cancer patients. Bioscore staging model was proposed by MD Anderson team. In this staging model incorporation of biologic factors into AJCC staging system had prognostic impact on breast cancer patients survival. Our study included 317 patients with non-metastatic surgically treated female breast cancer patients who were identified retrospectively in the period from January 2015 to December 2018 at Clinical Oncology Department of Assiut University Hospital. Mean age of enrolled women was 50.05 ± 10.90 years with range between 24 and 78 years old. Majority (84.2%) of the studied patients 267 was ≥ 40 years old. Out of those women; 129 (40.7%) women were pre-menopause and 188 (59.3%) were post-menopause. Most of our study cohort had stage II disease (49.5%). As regard histopathology invasive ductal carcinoma, not otherwise specified (NOS) was the most common type among enrolled patients (86.8%).patients had nuclear grade II (78.2%).Positive estrogen receptor, progesterone receptor and Her-2 receptor present in 230 (72.6%), 209 (65.9%), and 70 (22.1%) patients, respectively Thirty four (10.7%) patient developed local recurrence. It was noticed that bone metastasis developed in 47 (14.8%) patients, brain metastasis developed in 15 (4.7%) patients, liver metastasis developed in 24 (7.6%) patients and lung metastasis developed in 35 (11%) patients. Median follow-up was 40 of our study cohort months. Forty five (14.2%) patients missed during follow up while 46 (14.5%) were died and 226 (71.3%) patients.