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Abstract Summary Breathing discomfort contributes to worse outcomes among mechanically ventilated patient and had bad effects on ICU as long stay, so implementing breathing discomfort evaluation and nursing care are important to be done. The current study aimed to implement nursing care for the mechanically ventilated patients suffering from breathing discomfort to improve outcomes. The design of this study was quasi-experimental research design. This study was carried out in intensive care units of anesthesia department at assiut university hospital (general, trauma, critical care and coronary ICU). Moreover, this study was conducted to test the hypotheses: • Breathing discomfort was expected to have high prevalence rate among mechanically ventilated patients • Breathing discomfort was expected to have deleterious effects on the clinical outcomes • Nursing interventions for relieving breathing discomfort were expected to be effective. A purposive sample of 80 patients who were mechanically ventilated for >24 hrs. Breathing discomfort was evaluated according to patient conscious level and nursing interventions were done for study group and routine care for control group at Assiut University Hospital. Three tools were utilized to collect data pertinent to the study, which are Tool I: Patient assessment sheet Tool II: Breathing discomfort assessment: it consisted of two parts: Part I: Respiratory distress observation scale (RDOS) Part II: Dyspnea Visual Analogue Scale (VAS) Tool III: Factors affecting breathing discomfort Tool IV: Patient outcomes assessment. Finding of the present study revealed that there was high statistical significant difference between study group and control group in relation to arterial blood gases and haemodynamic parameters one hour after intervention. Concerning to clinical outcomes; 57% of control group experienced weaning failure versus 35% in study group, and concerning to mean length of stay in ICU, it was found (14.8±12) and (21±2.3) for study and control group respectively with highly significant statistical difference between them (P=.004) Summary 80 Conclusion: Implementing nursing care among the mechanically ventilated patients was effective in relieving breathing discomfort. Based on the study findings, the following recommendations are suggested: o Applying breathing discomfort evaluation as a routine care for all patient in ICUs o Patients with high score of breathing discomfort encouraged for chest physiotherapy for better score, and then breathing discomfort evaluation is applied again. o Providing nursing educational program for nurses about nursing care for relieving breathing discomfort. o Reapply this research on a larger probability sample acquired from different geographical areas in Egypt for generalization |