الفهرس 
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Abstract
The aim of the present work was to assess the role of H. pylori in the progression of chronic liver diseases.
This study was conducted on 200 participants included 40 patients with chronic viral hepatitis, 80 patients with liver cirrhosis, 40 patients with HCC on top of liver cirrhosis and 40 healthy persons of matched age and sex as controls. Patients and controls were selected from inpatients and outpatients clinic of Tropical Medicine department Menoufia University hospital in the period between July 2018 and December 2019. Patients were 119 (74.3%) males and 41 (25.6%) females. Their ages ranged from 28 to 63 years old.
Informed consents were obtained from all patients and controls included in the study which approved by the local ethics committee.
Patients and controls were classified into the following groups:
• group I: 40 patients with chronic viral hepatitis.
• group II: 80 patients with cirrhosis.
• group III: 40 patients with HCC on top of liver cirrhosis.
• group IV: 40 healthy persons as controls.
Diagnosis of chronic viral hepatitis, liver cirrhosis was done by history, clinical examination, laboratory investigations and ultrasound findings. Diagnosis of HCC was confirmed by characteristic features of triphasic CT.
For this purpose, all patients were subjected to the following:
Full history taking, full clinical examination and investigations including: Complete blood count, liver function tests, serological tests for viral markers by ELISA (HCVAb, HBsAg), serum Alpha fetoprotein (AFP) and H. pylori Ag in stool, upper GI endoscopy and abdominal ultrasonography.
Triphasic CT was done for HCC patients.
Statistical analysis of the presenting data revealed:
There was no significant difference between studied group regarding sex and age.
There was significant difference between patient groups regarding history of generalized weakness, anorexia, weight loss, right hypochondrial pain, ascites, hepatic encephalopathy & hematemesis and/or melena.
Regarding general examination, there was significant difference between the three patient groups as regards cachexia, ecchymosis and lower limbs oedema with frequent cases were observed in cirrhotic and HCC patients compared to chronic hepatitis patients.
Local abdominal examination revealed that, there was significant difference between patient groups regarding the presence of tender liver, hepatomegaly, splenomegaly as well as the presence and grade of ascites.
Regarding ultrasound findings in studied groups, there was significant difference between groups as regards liver size and echogenicity, spleen size, presence of splenic collaterals, portal vein size and patency, the presence and amount of ascites & the presence of hepatic foacl lesion and its size.
There was significant difference between four studied groups regarding upper GI endoscopy findings where PHG and oesophageal varices present in cirrhotic and HCC patient groups.
There was no significant difference between patients with liver cirrhosis and patients with HCC regarding the grade of oesophageal varices.