الفهرس 
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Abstract
ABSTRACT
In This work present an efficient green one pot reaction of chalcone (1a) [(E)-1-(3, 4-Dichlorophenyl)-3-(4-Methoxyphenyl) prop-2-en-1-one] with ethyl cyanoacetate, ethyl acetoacetate and diethyl malonate to afforded 8-Azacoumarin promoted with grinding and ultrasonic reaction conditions. Synthesis of newly pyrazole derivatives via heterocyclic ring opening of 8-Azacoumarin followed by ring closure was presented.On the other hand, one pot reaction of chalcone (1b) [(E)-1-(3, 4-Dichlorophenyl)-3-(4-Biphenyl) prop-2-en-1-one] or β-aroyl acrylic acid with isatin and hydrazine derivatives e.g. hydrazine hydrate, methyl hydrazine, phenyl hydrazine or acetohydrazide as multicomponent reaction to afford newly Spiro [indoline-3,3’-pyrazol]-2-one derivatives as interesting pyrazole derivatives. Fused furanone and pyridazinone rings with Spiro-pyrazole can be synthesized. In an attempt to achieve these Spiro-pyrazole derivatives containing hydrophobic groups to improve their antibacterial activities. Efficient green synthesis can be well progressed to afford the good yield of new heterocyclic products that were characterized by IR, 1H-NMR, MS and microanalytical data. Antibacterial evaluation for the synthesized compounds exhibited good cytotoxicity such as most potent pyrazole derivatives that displayed antibacterial activity. The Density Functional Theory (DFT) has revealed electronic and structure of spiropyrazole derivatives and their reacting species to support the proposed mechanism and antibacterial characterization.