الفهرس 
Rheumatoid ArthritisOnly 14 pages are availabe for public view
 |  | from | 128 |  |  |
| | | from | 128 | | |
Abstract
If left untreated, rheumatoid arthritis is a persistent inflammation of the joints with severe morbidity and mortality. The joints are targeted primarily by RA, usually several joints at once. RA is frequently affect joints in the palms, wrists, and knees. In a joint with RA, the joint’s lining becomes inflamed, causing injury to joint tissue. Long-lasting or chronic pain, unsteadiness, and deformity may be caused by this tissue damage. Progranulin is a growth factor of 593-aa that is secreted from cells regulated by its 17 amino acid signal peptides, also known as the cell-derived growth factor GRN-epithelin precursor, proepithelin, acrogranin, and GP88/PC. It has significant functions in several processes, including immune response and the development of cancer. Recent studies have shown that PGRN is a therapeutic option for rheumatoid arthritis because of its ability to bind to the tumor necrosis factor receptor. There is an exceptionally wide range of biological activities of tumor necrosis factor (TNF). Cytotoxicity to tumor cell lines was one of the first functions to be identified that resulted in its name tumor necrosis factor.TNF-alpha is produced predominantly by monocytes and macrophages, but also by fibroblasts, T-cells and B-cells. It is one of the main molecules of cytokines that induces inflammation in RA.