الفهرس 
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Abstract
Obesity is the global epidemic of the 21st century. Obesity is a significant burden to any healthcare system.
Insulin resistance has been suggested to be the primary mediator of the metabolic syndrome and obesity.
Metabolic syndrome is associated with increased risk of coronary heart and cerebral diseases and mortality.
LAP is a better marker/index to describe lipid over-accumulation in relationship to central obesity and CVD risk.
VAI is a sex‐specific surrogate marker of visceral adiposity accumulation and dysfunction. It is the best for diagnosing metabolic syndrome compared with many anthropometric indices.
AIP is the best determinant for fractionated esterification rate of HDL-C and more useful than routine lipid parameters.
AIP is a critical index that can be used for cardiac risk estimation and atherosclerosis. It is suggested that there is an association between the level of SELENOP and an abnormal glucose metabolism.
Selenoproteins play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection.
Se P is a Se-rich hepatokine with antioxidant functions and adversely affects insulin sensitivity and glucose metabolism and altered in individuals with metabolic syndrome.
This study included (90) individuals, were divided into two groups; (50) overweight and obese and (40) lean.
Physical, laboratory and special investigations were done to all (90) subjects.
There is a significant difference as regards weight, BMI, WC, HC, waist –hip ratio and waist –height ratio.
There is a significant difference between the two groups as regards blood pressure.
There is a significant difference between the two groups as regards serum total cholesterol and HDL-cholesterol, but serum triglycerides and LDL-cholesterol are non-significant.
There is a significant difference between the two groups as regard lipid accumulation product, visceral adiposity index and atherogenic index of plasma.
There is a significant difference between the two groups as regards fasting blood sugar, serum insulin and HOMA-IR.
All obese subjects are insulin resistant, but only 57.5% of lean individuals is insulin resistant.
There is a significant difference between the two groups as regards serum selenoprotein P.
In the current study all variables are significantly correlated with serum selenoprotein P in all subject Groups.
Se P is specific and sensitive in detecting insulin resistance with sensitivity 71.23% and specificity 82.35%.
Visceral adiposity index is sensitive in detecting insulin resistance with sensitivity 93.15%.
As regarding univariate analysis we found that weight, BMI, waist and hip circumferences, waist-hip ratio, waist-height ratio, LAP, AIP,systolic and diastolic BP, HDL and total cholesterol, HOMA-IR, serum insulin concentration, FBS and VAI are the most independent factors affecting selenoprotein P in total sample.
As regarding multivariate analysis we found that hip circumference and serum insulin concentration are the most independent factors affecting selenoprotein P in overweight and obese subjects.
As regarding univariate analysis we found that waist and hip circumferences, WHR, serum insulin concentration, HOMA IR and VAI are the most independent factors affecting selenoprotein P in overweight and obese subjects.