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Abstract The current investigation has been conducted to investigate the effect of tofu as combined with plums, guava , mango and mix fruits on diabetic rats and hypercholesterolemic rats. Fifty five adult male albino rats , each weighting (150 ±10g) were used in this study. The first group fed on basal diet and injected with alloxan 150mg/kg body weight to induce diabetic rats and the other group fed on the hyperlipidimic diet is the basal diet with addition of 2.5% cholestrole and 10% cheeptail for feeding rats 3week to induce hypercholesterolemic rats . All rats were fed on control diet for seven days before the beginning of experiments for adaptation and as follows : Diabetes in Albino Rats: group (1): Negative control group fed on basal diet . group (2): Positive control group diabetic rats fed on basal diet. group (3): Diabetic group treated with 5% plums juice with tofu. group (4): Diabetic group treated with 5% guava juice with tofu. group (5): Diabetic group treated with 5% mango juice with tofu. group (6): Diabetic group treated with 5% mixture of plum, guava and mango juices with tofu. Hypercholesterolic in Albino Rats: group (7): Positive control group Hypercholesterolemic rats fed on basal diet. group (8): Hypercholesterolemic group treated with 5% plums juice with tofu. group (9): Hypercholesterolemic group treated with 5% guava juice with tofu. group (10): Hypercholesterolemic group treated with 5% mango juice with tofu. group (11): Hypercholesterolemic group treated with 5% mixture of plum, guava and mango juices with tofu. Blood serum samples were used for estimation of : * 1-Fasting serum glucose. 2-Serum GOT, GPT and ALP. 3-Serum lipid profile. a-Total cholesterol. b-Ttiglycerides. c-HDL cholesterol. d- LDL cholesterol. e- VLDL cholesterol. 4-Serum kidney function. The obtained results can be summarized as following: Biological resalts of diabetic rats : 1-Body weight gain % ,Feed Intake &FER: a-Hyperglycemic resulted in the increase of BWG, FI and FER. b- Feeding on Tofu with plums 5%, guava 5% , mango 5% and mix fruit juices 5% raised BWG, FI and FER . c- Hyperglycemic (control”+”) raised the liver , heart , lungs , kidneys and spleen relatively weight . 2- Serum glucose : a-The best result was observed for group 6(rats fed on Tofu by 5% with mix fruit juice 5%) . 3- Lipid profile : a- Total cholesterol :The lowest mean value were observed for lowering total cholesterol of diabetic rats to group 6 (rats fed on tofu by 5% with mix fruits5%) . b- Triglycerides :Hyperglycemic rats fed on tofu by 5% with Mix fruits5% showed the lowest mean value of TG . c- VLDL :The best mean value of VLDL was noticed for group 6 ( Hyperglycemic rats fed on tofu by 5% with mix fruit juices 5%) . d- HDL :Diabetes rats fed on Tofu by 5% with guava 5%and Tofu by 5% with Mix fruits5% (group 4, 6) showed the best treatment . e- LDL: The lowest mean value of serum LDL-c was recorded for group 5( rats fed on tofu by 5% with mango juice 5%) . |