الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Transitional cell carcinoma (TCC) of the renal pelvis is a rare aggressive disease, it is less than 1% of genitourinary cancers.
The purpose of this study is to determine the pattern of failure of renal pelvis non metastatic transitional cell carcinoma and to identify the different prognostic parameters for survival outcome.
This is a retrospective study conducted at Clinical Oncology Department in Alexandria University where patients with renal pelvis non metastatic transitional cell carcinoma treated between January 2007 and December 2017 were included.
After analysis, the results showed that 36 patients were eligible for further analysis and the median age of patients was 61 years. About 60% of patients had good performance status and also 60% of patients had history of cigarette smoking.
Concerning the treatment outcome, 47.2% of patients had relapse. Distant failure occurred more common in comparison to local failure. Lungs (22.2%) was the more affected site for distant failure followed by bones (11.1%).
Local failure free survival (LFFS) rate at 5-years was 71.0%. The prognostic factors significantly affecting LFFS in our study were tumor size (P=0.025) and receiving adjuvant chemotherapy (P=0.001).
In the current study, the 5-years DFFS rate was 60.3%. The following parameters namely: good performance status (P=0.019), the stage of disease (P=0.024), perineural invasion (P=0.027), lymphovascular invasion (P=0.003), the type of surgery done (P=0.014) and receiving radiotherapy (P=0.019) were significantly associated with DFFS.
The 5-years overall survival (OS) was 82.5%. Performance status (P=0.019), tumor size (P=0.021), lymphovascular invasion (P=0.020), the type of surgery done (P=0.032) and the type of failure (P=0.027) were the prognostic factors for OS.