الفهرس 
NEONATAL HYPERBILIRUBINEMIAOnly 14 pages are availabe for public view
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Abstract
Background: Neonatal jaundice is one of the most common problems that affect newborn infants, and phototherapy is usually used for treatment. Phototherapy is generally considered a very safe and well-tolerated treatment for hyperbilirubinaemia. However, clinical users should be aware of the unwanted effects of using phototherapy. Affection of neonatal immune system due to phototherapy has been reported. Objectives: Evaluation of the effect of phototherapy on neonatal immune system through measuring the level of CD4+ lymphocytes. Methods: A prospective cohort study was conducted on full term newborns assigned to three groups: group1 neonates with hyperbilirubinemia treated by conventional phototherapy, group2 neonates treated by LED phototherapy and healthy neonates as control group. The percentages and absolute counts ofCD4+ lymphocytes were measured by flow cytometry before phototherapy and 48 h after exposure. Results: The study showed a significant decrease in CD4+ percentage in patients after 48 h of exposure to conventional phototherapy (P value < 0.05). There was a significant decrease in CD4+ absolute counts after 48 h of exposure to both types of phototherapy. More studies are needed to determine the effect of intensive phototherapy on immune system. Conclusion: Conventional and LED phototherapy which are used in the treatment of neonatal hyperbilirubinemia, caused a decrease in CD4+ absolute count 48 hours after phototherapy. Also conventional phototherapy caused a decrease in CD4+% 48 hours after exposure.