الفهرس 
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Abstract
This study aimed to assess the added value of 3D double inversion recovery (DIR) in the detection of brain lesions in multiple sclerosis patients.
The study was conducted on thirty patients diagnosed as having remitting relapsing multiple sclerosis according to their clinical presentation and the typical MRI findings. They were six males and twenty four females. Their ages ranged between fifteen years and fifty two years with a mean age of twenty eight years. All the patients were subjected to full history taking and thorough clinical examination.
Magnetic resonance imaging was performed on 1.5T Philips Gyroscan Intera whole body scanner System using a standard head coil. Imaging included conventional MRI and 3D double inversion recovery in the sagittal orientation which were orthogonally reformatted into the axial and coronal planes.
The MS lesions were identified on the T2WI, FLAIR and 3D DIR sequences and classified according to their anatomic location into: infra-tentorial, periventricular, DWM, corpus callosum, sub-cortical, intra-cortical lesions and mixed white matter-gray matter lesions.
• The findings of our study were:
1. Overall, the highest number of GM and WM lesions, was detected on the 3D-DIR Sequence (916). FLAIR images showed (731), while T2 weighted MR images showed (718). The DIR was statistically significant compared to T2WI (p = 0.0012*) and FLAIR (p = 0.007*).
2. The 3D-DIR sequence could depict the largest number of supra-tentorial lesions (830) compared to T2WI (597) and FLAIR (678) sequences, showing statistically significant difference compared to FLAIR (p=0.001) and T2WI (p=0.001).
3. 3D DIR sequence was superior in depicting intra-cortical lesions (49) in comparison with both T2-WI (3) and FLAIR (7) sequences and it showed statistically significant difference compared to T2WI (p=0.0019) and FLAIR (p=0.008).