الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Type 2 diabetes mellitus (T2DM) and hypertension are the common
chronic diseases which mainly associated to the development and progression
of end
-
stage renal disease (ESRD) leading to morbidity and mortality. A
genetic susceptibility to ESRD may be relate
d to T2DM and hypertension.
Gene polymorphisms associated with the renin
angiotensin
aldosterone
system (RAAS) were broadly inspected in patients with diabetic nephropathy
(DN).
All components of the systemic RAAS are also present in local (tissue)
RAAS,
and for example in the kidneys, the local effects accelerate the
progression of renal disease .Data suggest that the activation of intrarenal
angiotensinogen (AGT) production plays an important role in the
development of DN. Urinary AGT was proposed as a p
ossible early marker of
DN, as it reflects intra
-
renal RAAS status in chronic glomerulonephritis