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Abstract Patient safety is a critical component of healthcare quality. With growing international interest in patient safety, there is increasing need to monitor the safety of organizations and evaluate safety initiatives. Measuring the scale and impact of safety incidents, however is a major challenge, and estimates of deaths caused by such incidents vary widely. Agency for Healthcare Research and Quality )AHRQ( developed the Patient safety indicators (PSIs). The Patient Safety Indicators (PSIs) were developed as a tool for hospitals to identify potentially preventable complications and improve patient safety performance. In previous studies, PSIs have been associated with increased length of stay (LOS), mortality, unplanned readmission. The PSIs were developed after a comprehensive literature review, analysis of available ICD-9- CM1 codes, review by a clinician panel, implementation of risk adjustment, and empirical analyses. Very recently, AHRQ took steps to enhance the utility of this tool by releasing a new version of the PSI software that uses ICD -10, which contain 18 PSIs. Research Question: Do patient safety indicators affect the clinical outcomes including inpatients length of stay, mortality and 30-day readmission at Cardiothoracic Surgery patients?Objective: To measure the association between Patient Safety Indicators (PSIs) and clinical outcomes at Cardio-thoracic Surgery hospital including inpatient length of stay, mortality from any cause during hospitalization and 30-day unplanned readmission. The current study is an exploratory prospective cohort study conducted to follow up patients from admission till 1 month after discharge. The target population of the study was all admitted patients to the Cardio-thoracic Surgery Hospital. The sample was all patients admitted who fulfill the inclusion criteria during the 3 months of the study. Main findings showed that males constituted about (59%) of the 330 included patients and mean age was (48.78±14.63). Most of the patients were married (77%) and live in urban areas (54%). The studied participants were mainly admitted from outpatient clinic (elective cases) (75%) and most of them (94%) were admitted to internal department. The most common performed surgery was cardiac surgeries (75%). At the time of discharge, (92%) of the studied sample were at improvement status and (5%) died. Fifty four percent of the studied cases stayed in the hospital more than 10 days and the unplanned readmitted cases within 30 days accounted for (6%). The incidence rate of PSI3 (pressure ulcer rate) was 67.7 per 1000 discharges at risk. The risk of development PSI3 in patients more than 60 years old is 8.6 times in cases less than 36 years old (p= 0.071). The risk of death in cases developed PSI3 is 8.7 times the risk of death in cases without PSI3 (p=0.00). The risk of unplanned readmission within 30 days in cases with PSI3 is 2.3 times the risk of readmission in cases without PSI3 (p= 0.553). The risk of staying more than 10 days at the hospital in patients developed PSI3 is 1.5 times the risk in patients without PSI3 (p= 0.008). The incidence rate of PSI9 (perioperative hemorrhage or hematoma) was 49.54 per 1000 discharges at risk. The risk of development PSI9 in patients admitted directly to ICU is 5.6 times in patients admitted to internal department (p=0.008). The risk of death in cases developed PSI9 is 2.4 times the risk of death in cases without PSI9 (p=0.215). The risk of unplanned readmission within 30 days in cases with PSI9 is 2.4 times the risk of readmission in cases without PSI3 (p= 0.283). The risk of staying more than 10 days at the hospital in patients developed PSI9 is 1.26 times the risk to stay more than 10 days in patients without PSI9 (p= 0.26). The incidence rate of PSI13 (postoperative sepsis) was 40.6 per 1000 discharges at risk. The risk of death in cases developed PSI13 is 4.74 times the risk of death in cases without PSI13 (p=0.005). The risk of readmission within 30 days in cases developed PSI13 is 3.4 times the risk of readmission in cases without PSI13 (p=0.163). The incidence rate of PSI10 (postoperative acute kidney injury required dialysis) was 12.54 per 1000 discharges at risk. All cases developed PSI10 were dead. The incidence rate of PSI12 (perioperative pulmonary embolism or DVT) was 6.21 per 1000 discharges at risk. The association between the occurrence of PSI12 and the studied clinical outcomes was statistically insignificant. There was no death or readmission reported in cases developed PSI12. The current study reported only one case with PSI16 (transfusion reaction). There were no cases reported with PSI5 (retained surgical items) or PSI7 (CVC blood stream infection). from the current study, it is concluded that the PSI3 (pressure ulcer rate) was the highest incidence rate, then PSI9 (perioperative hemorrhage or hematoma), then PSI13 (postoperative sepsis). Almost all PSIs associated with death, readmission within 30 days and increased length of stay. The association between mortality and occurrence of patient safety indicators is statistically significance especially PSI3, PSI10 and PSI13. The association between staying 10 days in the hospitals and the occurrence of patient safety indicators is statistically significance especially PSI3, PSI13. The recommendations include continuous assessment of patients to early detect PSI cases to prevent further complications. Training sessions for physicians and nurses about the importance of patient safety measures such as patient safety indicators. Giving the attention to the full documentation in the medical records for the complications and PSI measurements. |