الفهرس 
1.1 TuberculosisOnly 14 pages are availabe for public view
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Abstract
Tuberculosis is one of the most pervasive diseases caused mainly by Mycobacterium tuberculosis. It considered a highly infectious airborne and chronic bacterial disease usually infecting the lungs. The World Health Organization recommended Isoniazid and rifampicin as the first-line anti-tuberculosis drug. The applying of anti-tuberculosis drugs is accompanied by toxic reactions in tissues, especially in the liver causing hepatitis.
The liver disease that is resulted from the drug side effect is considered a globally health problem, so most researches keen on studying the traditional herbal medicines especially that possess hepatoprotective activity to deal with the severe undesirable side effects of synthetic drugs. There is an urgent need for using herbal plants as they have significant role in handling with liver disorders.
Moringa olifera is one of the most important herbal plants that are used in curing many diseases. It possesses anti-inflammatory effects, antihypertensive activity, biological activities, antidiabetic and hypocholesterolemic effects. This study focused on the protective and therapeutic roles of Moringa olifera against the induced- Rimactazid (consists of both INH+RM) hepatotoxicity.
• Experimental animals were treated for 8 weeks according to the experimental design. They were classified into ten groups.
• The hepatotoxicity is induced through elevating serum levels of ALT, AST, GGT, ALP, total protein, total bilirubin and reduction in albumin level by 4.66, 6.93, 4.17, 1.1, 1.16, 2.88, 0.6 times, respectively when compared to NG. The liver content of MDA and the (T.A.C) also increased by 4.29 and 4 times, respectively, as compared to NG.
• The toxicity is also induced by significantly increasing in TG, Cholesterol and HDL- cholesterol levels for DG compared to NG.
• There is also a kidney toxicity induced by a significant increasing in Creatinine and Urea levels for DG compared to NG.
• The treatment with MO extract in MG1, 2 & 3 significantly reduced serum levels of ALT by 1.56, 3.94 and 3.94 times, respectively, AST by 4.08, 3.13 and 2.21times, respectively, GGT by 4.30, 5.44 and 1.33 times, respectively, ALP by 1.05, 1.22 and 1.24 times, respectively, total protein by 1.13, 1.08 and 1.5 times respectively, total bilirubin by 1.64, 2.3 and 1.53 times, respectively and elevated the albumin level by 1.34, 1.28 and 1.03 times, respectively when compared to DG.
• The treatment with MO extract in MG1,2 and 3 significantly reduced liver content of MDA by 2.29,1.93 and 2.07 times, respectively and the (T.A.C) also reduced by 1.88,1.88 and 1.88 times, respectively when compared to DG.
• The treatment with MO extract in MG1, 2 and 3 significantly reduced the TG, Cholesterol and HDL- cholesterol levels when compared to DG.
• The treatment with MO extract in MG1, 2 and 3 significantly reduced the kidney toxicity by decreasing significantly the Creatinine and Urea levels when compared to DG.
• The treatment with MO extract in MG 4, 5 and 6 significantly reduced serum levels of ALT by 3.14, 2.8 and 3.95 times, respectively, AST by 2.12, 1.66 and 1.68 times, respectively, GGT by 5.55, 4.17 and 4.14 times, respectively, ALP by 1.07, 1.08 and 0.94, times respectively, total protein by 1.18, 1.21 and 1.15 times, respectively, total bilirubin by 2.56, 3.29 and 2.86 times, respectively and elevated the albumin level by 1.31, 1.59 and 1.59 times, respectively when compared to DG.
• The treatment with MO extract in MG 4, 5 and 6 significantly reduced liver content of MDA by 3.01, 4.44 and 3.98 times, respectively and the (T.A.C) also reduced by 2.9, 4.57 and 3.56 times, respectively when compared to DG.
• The treatment with MO extract in MG 4, 5 and 6 significantly reduced the TG, Cholesterol and HDL- cholesterol levels when compared to DG.
• The treatment with MO extract in MG4, 5 and 6 significantly reduced the kidney toxicity by decreasing significantly the Creatinine and urea levels when compared to DG.
• Histopathological examination also confirmed our laboratory analysis where the group that administrated with RimactazidR show disorganization of hepatic cords and necrobiotic changes of hepatocytes characterized by focal necrotic foci and hydropic degeneration of hepatocytes. In contrast the groups that administrated by Moringa extract revealed the cell necrosis of the hepatocytes in all its groups especially the MG7.
• It is concluded that the Moringa olifera extract might be used as hepatoprotective therapy with anti-tubercular drugs and also as auxiliary drug in treatment of many liver disorders.