الفهرس 
CONGENITAL HEART DEFECTSOnly 14 pages are availabe for public view
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Abstract
Background: Interactions between genetic and environmental factors, including modifiable maternal nutrition and lifestyle, play a significant role in the pathogenesis of most congenital heart defects (CHD). The aim of this study was to investigate associations between periconceptional maternal vitamin D status and the prevalence of CHD in offspring.
Methods: A case-control study was performed in 36 mothers of a child with CHD and 37 mothers of a child without CHD from Ain Shams University Children Hospital in the period between January 2019 and June 2019. Maternal blood was obtained to determine serum 25-hydroxyvitamin D. The 25-hydroxyvitamin D concentration was stratified into a deficient<20 ng/ml, moderate deficiency 21-29 ng/ml and adequate >30 ng/ml status above 150 ng/ml presents high risk of toxicity.
Results: Our study showed statistically significant difference between groups according to maternal vitamin D level in ng/ml within 29 days postpartum. Mean vitamin D level in group 1 (Mothers with congenital heart anomalies in offspring) was 18.35 ng/ml however mean maternal vitamin D level of controls group 2 (mothers with no congenital anomalies in offspring) was 30.57 ng/ml. In the group 1 63.9% of mothers had deficient vitamin D level, 16.7% had moderate deficiency and only 19.4 % had an adequate level of vitamin D. On the other hand in the group 2 37.8% of mothers had deficient vitamin D level, 10.8% had moderate vitamin D deficiency and 51.4% of mothers had an adequate vitamin D level and there were no mothers with toxic level of vitamin D which shows the strong statistically significant relation between maternal vitamin D level and Congenital heart anomalies in offspring.
Conclusion: A compromised maternal vitamin D status is associated with an increased prevalence of CHD in offspring. Therefore, improvement of the periconceptional maternal vitamin D status is recommended.