الفهرس 
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Abstract
This study was a prospective observational study which conducted in Ain shams university hospitals on 60 cases of polytrauma patients who have ISS more than 15.
Acute Kidney Injury (AKI) is a common complication of severe trauma patients and is associated with increased morbidity and mortality. Injury Severity Score (ISS) > 15 represents approximately 10% of all trauma patients in intensive care unit (ICU); furthermore, 23% of them developed AKI and 10% required Renal Replacement Therapy (RRT).
Renal failure related to rhabdomyolysis is caused by renal vasoconstriction, ischemia, myoglobin cast formation, direct cytotoxic effect of myoglobin and hyperuricemia. AKI is classified according to RIFLE classification (acronym for Risk, Injury, Failure, Loss and End-stage) which based on changes in serum creatinine and urine output.
The primary outcome of the study was to correlate between the AKI by using RIFLE criteria and the trauma severity by using ISS .While; the secondary outcomes were; identifying the incidence of AKI in polytrauma patients, the length of ICU and hospital stay and 28 days mortality.
The results of our present study could be summarized as follows:
• There was no correlation between the incidence of AKI by using RIFLE criteria and the severity of the trauma by using ISS.
• Incidence of AKI the percentage was (45 %) among all the studied cases.
• According to RIFLE criteria, within this population, patients were classified as (21.7%) of the patients in the Risk stage; (18.3%) of the patients in Injury stage, and (5%) of the patients in Failure stage.
• There was statistically significant difference between AKI and non-AKI groups regarding risk factors, percentages of sepsis, rhabdomyolysis, drugs, abdominal trauma and hypovolemic shock which were higher in AKI patients than non-AKI patients.
• Increased serum phosphorus and creatine kinase levels among AKI patients than non-AKI patients.
• There was no statistically significant difference between AKI patients and non-AKI patients regarding mechanical ventilation, ICU stay, Hospital stay and 28d Mortality.