الفهرس 
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Abstract
Seventy adult male albino rats (Sprague Dawly) weighing 180-200 g were used in this study. They were divided into seven groups , ten rats each ; group І (normal control) received nothing , group П A, B (sham control ) ingested (GB) tablets (200 mg/kg , BW) orally daily for 21 days , group Ш A, B (ISO treated group- ISO withdrawal group) injected Isoproterenol (85 mg/ Kg,BW) subcutaneously on the 20th and 21st day , group IV A, B (GB and ISO treated groups ) : injested GB daily for 21 days , thereafter ISO s.c on the 20th and 21st day . Then sacrificed 24 hours after the second ISO dose , group I,IIA were sacrificed 24 hours after the last dose of GB ; IIIA ,IVA, were sacrificed 24 hours after the second dose of ISO ; II B were sacrificed 21 days after the last dose of GB,IIIB,IVB groups were sacrificed 21 days after the second dose of ISO. Heart specimens were processed for light and electron microscopic examination.
Histological examination of rat ’s heart section induced myocardial necrosis with isoproterenol in the form of focal lesions in many sections and fragmentation of muscle fibers. Ginkgo biloba pretreated animals revealed minimal myocardial injury when compared to ISO-treated hearts indicating the cardioprotective effect of GB .
Key Words : Ginkgo biloba; Cardio prophylactic; Antioxidant activity; Isoproterenol