الفهرس 
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Abstract
The current work aimed to study the relation between residual kidney function in hemodialysis patients and quality of life and cognitive function. The present study was carried out on seventy-eight patients treated by chronic hemodialysis for more than six months in Mansoura Nephrology and Dialysis Unit. Residual kidney function was measured for patients who pass urine ≥100ml/day, and the patients were divided into two groups according to presence or absence of residual kidney function. Medical history taking and basic laboratory investigations (blood hemoglobin, and serum TSAT, ferritin, calcium, phosphorus and PTH) were performed. In addition dialysis adequacy measured by KT/V, as well as serum homocysteine levels were investigated. Moreover, KDQOL-SF™ version 1.3 for assessing quality of life and MoCA score for assessing cognitive function were carried out. In the present work, patients with RKF had statistically significant lower values compared to those without RKF regarding hemodialysis duration, serum homocysteine level, On the other hand, there was no statistically significant difference between the two study groups regarding age, gender, serum calcium, phosphorus, PTH, TSAT, ferritin, blood hemoglobin, and KT/V. According to RKF status, patients with RKF had significantly higher scores for KDQOL domains; the symptom problem list, cognitive function, sleep, overall health, physical functioning, role physical, pain, general heath, role emotional, social function, energy/fatigue and PCS in comparison with patients without RKF. In addition, Total score of MoCA was demonstrated to be significantly higher in RKF group compared to non-RKF group. There was a statistically significant negative correlation between RKF and both serum homocysteine and hemodialysis duration. On the other hand, among items of KDQOL questionnaire, there was a significant positive correlation between RKF and symptom problem list, cognitive function, sleep, overall heath, physical functioning, role physical, pain, general heath, role emotional, social function, energy/fatigue and PCS. Also, among the items of the MoCA score, there was a statistically significant positive correlation between the measured RKF and the total MoCA score. The data of the current results pointed out that, there were statistically significant positive correlations between the PCS and both of the measured RKF and the total MoCA score. On the other hand, had significant negative correlations with patient’s age and hemodialysis duration. Also, there were statistically significant positive correlations between the MoCA score and homocysteine level and both of PCS and MCS. While the patient’s age and measured RKF had a negative correlation with the MoCA score. On multivariate analysis, hemodialysis duration was the only predictor for RKF; whereas age was a significant predictor for PCS; and MoCA score could be significantly predicted by age, duration of dialysis and homocysteine Level.