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العنوان
Effect of Intra-Operative Single Dose of Dexamethasone On Post-Tonsillectomy Pain in Children :
المؤلف
Sakr, Mohamed Abd El-Maged.
هيئة الاعداد
باحث / محمد عبد المجيد محمد صقر
مشرف / احمد سامي الجندي
مشرف / محمد عادل خليفة
مشرف / محمود فوزي مندور
الموضوع
Otorhinolaryngology.
تاريخ النشر
2021.
عدد الصفحات
88 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم المناعة والحساسية
تاريخ الإجازة
21/4/2021
مكان الإجازة
جامعة طنطا - كلية الطب - الاذن والانف والحنجرة
الفهرس
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Abstract

Background Tonsillectomy continues to be one of the most common surgical procedures performed worldwide. Despite advances in anaesthetic and surgical techniques, post tonsillectomy pain remains a significant clinical problem for the patient, family and physician Objectives The aim of this study is to clarify the effect of Intra-operative single dose of dexamethasone on posttonsillectomy pain in children and to determine its significance. Literature Search Strategy We searched the following databases from their inception for published, unpublished and ongoing trials: the Cochrane Ear, Nose and Throat Disorders group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL; PubMed; EMBASE; LILACS; KoreaMed; IndMed; PakMediNet; ClinicalTrials.gov; ICTRP (International Clinical Trials Registry Platform), Google and other sources search terms included: Intra-operative, single dose, dexamethasone ,posttonsillectomy pain, children We also scanned the reference lists of identified publications for additional trials. We had no language, publication year or publication status restrictions. Data collection and analysis Two review authors scanned the titles and abstracts of retrieved citations and applied the inclusion criteria. We retrieved included studies in full, and extracted data. Two review authors independently assessed trial quality. We calculated Risk Ratio for dichotomous data and Standardized mean difference for continuous outcomes. We performed Fixed – effects Meta-Analysis with assessment of heterogeneity. Sensitivity analysis was undertaken whenever there was uncertainty about a certain decision to know if the final findings are robust to these decisions. Main results Seven randomized controlled trials from the total participants were included in analysis of posttonsillectomy pain The seven studies had overall “low” risk of bias. However, there was no significant heterogeneity. A statisyically significant reduction in pain as measured by VAS Authors’ conclusions Intravenous dexamethasone statistically significantly decreases posttonsillectomy pain in children.