الفهرس 
صفحة العنوان باللغة الانجليزيةOnly 14 pages are availabe for public view
 |  | from | 125 |  |  |
| | | from | 125 | | |
Abstract
Leukemia originates in the bone marrow and results in the production of a large number of abnormal white blood cells. There are various types of leukemia. Acute myeloid leukemia (AML) is clinically and molecularly heterogeneous disease. Currently, cytogenetic findings provide the most important prognostic information and are used to guide risk-adapted treatment strategies. However, by conventional cytogenetic techniques, karyotype abnormalities are detected in only half of all AML cases and the other half are commonly described as normal-karyotype AML and therefore lack informative chromosome markers. The CD genes belong to a large family of genes called the cluster of differentiation. Many CD genes provide instructions for making proteins that are found on the surface of white blood cells (leukocytes) at various stages of their development. Genes contained within the family is 394 gene. one of them is CD47, which is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cellmigration, angiogenesis,presentationof cytokines, chemokines, and growth factors to the corresponding receptors, as well as in signaling for cell survival. All these biological properties are essential to the physiological activities of normal cells, but they are also associated with the pathologic activities of cancer cells. The previous observations raise the possibility that increased expression of CD47 might have a role in the pathogenesis of AML; hence in the present study CD47 gene and protein expression were